Hey guys! Are you on the hunt for some seriously comfy and breathable clothes? If you're a fan of 100% cotton like I am, then you're in the right place! We're diving deep into the world of American-made and designed cotton clothing brands. Get ready to explore a massive list of brands that are all about that pure, natural fiber life. Whether you're after everyday basics, stylish outfits, or something specific, this guide has got you covered. From established giants to up-and-coming brands, we've compiled a comprehensive list to help you discover the best in 100% cotton clothing right here in the USA. So, buckle up, because we're about to explore a ton of fantastic brands that prioritize quality, comfort, and, of course, the unbeatable feel of cotton. Let's get started and find your next favorite cotton pieces!

Why Choose 100% Cotton Clothing?

Alright, let's chat about why 100% cotton clothing is so awesome. First off, it's super comfortable. Cotton is known for its softness and breathability, making it perfect for any weather. It's like a gentle hug for your skin! Cotton is also hypoallergenic, which means it's less likely to cause skin irritation. This is a huge win for those with sensitive skin or allergies. But it's not just about comfort. Cotton is a sustainable choice too. It's a natural fiber, and when sourced responsibly, it can be a more eco-friendly option than synthetic materials. Plus, cotton clothes are generally pretty durable. They can withstand multiple washes and wears, making them a great investment. Choosing 100% cotton supports brands that value quality and longevity. You're not just buying clothes; you're investing in pieces that can last a while. Now, let's talk about the style factor. Cotton is incredibly versatile. It can be dyed in endless colors and woven into various fabrics, from lightweight t-shirts to heavy-duty denim. So whether you're after a casual look or something more dressed up, cotton has you covered. And let's not forget the feel. There's just something about the texture of cotton that makes you feel good. It's soft, breathable, and lets your skin breathe. In the long run, investing in 100% cotton clothing is worth it. You're getting comfort, style, durability, and a more sustainable choice all wrapped into one. And let's face it, nothing beats the feeling of putting on a well-made cotton garment. It's a classic choice for a reason!

The Top 100 Cotton Clothing Brands in the USA

Here’s the massive list of 100% cotton clothing brands that you've been waiting for. We've included a variety, so you can find something that fits your style and budget. The brands are not in any particular order, as it’s all about personal preference. Get ready to add some amazing brands to your shopping list!

1. American Giant: Known for its high-quality basics and commitment to American manufacturing, American Giant uses premium cotton for its durable, comfortable clothing. Their hoodies and tees are customer favorites.
2. Everlane: Everlane offers transparent pricing and focuses on modern essentials. Many of their items, like tees and sweaters, are made with high-quality cotton.
3. Marine Layer: Marine Layer is famous for its super-soft cotton fabrics, particularly their tees and sweatshirts. They use unique cotton blends to achieve an extra cozy feel.
4. Outerknown: Founded by surfer Kelly Slater, Outerknown emphasizes sustainability and uses organic cotton in many of its products, creating stylish and eco-friendly options.
5. Levi's: A classic brand that needs no introduction, Levi's offers a wide range of denim and casual wear, with many pieces made from high-quality cotton.
6. Buck Mason: Buck Mason focuses on timeless essentials with a vintage aesthetic. Their cotton tees and jeans are made for everyday wear.
7. Taylor Stitch: Taylor Stitch creates well-made, durable clothing with an emphasis on craftsmanship, including shirts, pants, and outerwear crafted from cotton.
8. MATE the Label: MATE the Label prioritizes organic cotton and sustainable practices, offering a range of comfy basics like tees, leggings, and loungewear.
9. Known Supply: Known Supply partners with artisans globally, and they offer a line of ethically-made cotton apparel, including tees and accessories.
10. Alternative Apparel: Alternative Apparel focuses on sustainable practices and offers comfortable, eco-friendly clothing, including tees, hoodies, and sweatpants.
11. Pact: Pact creates sustainable basics using organic cotton, focusing on comfort and ethical production. They have everything from underwear to dresses.
12. Boody: Boody is known for its eco-friendly bamboo clothing, but they also offer some 100% cotton options that are super soft and sustainable.
13. Tradlands: Tradlands focuses on timeless, high-quality clothing for women. They use a lot of cotton in their collection.
14. Kotn: Kotn works directly with cotton farmers in Egypt to produce high-quality, sustainable cotton apparel. Their offerings include tees, sweats, and more.
15. Organic Basics: Organic Basics is all about sustainable and ethical fashion, making great basics from organic cotton.
16. Cuyana: Cuyana focuses on minimalist, high-quality pieces, including cotton clothing. They are all about creating items that you will love for years.
17. L.L.Bean: L.L.Bean is an outdoor brand, and many of their casual clothing options use cotton for comfort and durability.
18. Uniqlo: Uniqlo offers a wide range of affordable and stylish cotton basics, from t-shirts to jeans.
19. Gap: Gap is a classic brand that offers a range of cotton clothing, perfect for everyday wear.
20. Old Navy: Old Navy provides affordable and trendy cotton clothing for the whole family.
21. Madewell: Madewell offers stylish and durable cotton clothing, with a focus on denim and casual wear.
22. J.Crew: J.Crew is known for its classic style and offers a wide range of cotton clothing.
23. Aerie: Aerie is all about comfortable loungewear, and many of their pieces are made from soft cotton.
24. Universal Standard: Universal Standard offers inclusive sizing and stylish cotton clothing for everyone.
25. H&M: H&M has a great range of cotton basics at affordable prices.
26. ASOS: ASOS offers a wide selection of trendy cotton clothing.
27. Urban Outfitters: Urban Outfitters provides trendy and unique cotton clothing options.
28. Free People: Free People offers bohemian-inspired cotton clothing.
29. Reformation: Reformation is all about sustainable fashion, and they have some great cotton options.
30. Eileen Fisher: Eileen Fisher creates timeless, sustainable clothing with a focus on cotton and other natural fibers.
31. Patagonia: Patagonia is all about outdoor gear, and many of their everyday wear options use cotton.
32. Faherty Brand: Faherty Brand offers stylish and comfortable cotton clothing inspired by surf and travel.
33. Rails: Rails creates soft and stylish cotton shirts and dresses.
34. Splendid: Splendid offers a range of super-soft cotton basics and loungewear.
35. Michael Stars: Michael Stars is known for its comfortable and stylish cotton tops and tees.
36. James Perse: James Perse focuses on minimalist, luxury cotton basics.
37. Velvet by Graham & Spencer: Velvet offers luxurious, soft cotton clothing for everyday wear.
38. Theory: Theory creates modern, minimalist cotton clothing for work and play.
39. Club Monaco: Club Monaco offers sophisticated cotton clothing with a focus on quality.
40. Equipment: Equipment is known for its classic cotton shirts and blouses.
41. Everlane: Everlane offers transparent pricing and modern essentials, with many of their items made from high-quality cotton.
42. Grana: Grana focuses on luxury basics at accessible prices, including cotton pieces.
43. Naadam: Naadam offers ethically sourced cashmere and other sustainable materials, with some cotton options.
44. Outerknown: Outerknown emphasizes sustainability and uses organic cotton in many of its products.
45. TenTree: TenTree focuses on sustainability and plants ten trees for every item purchased, with some cotton options.
46. Tentree: Similar to TenTree, but a different spelling, focusing on sustainability.
47. Threads 4 Thought: Threads 4 Thought is all about ethical and sustainable fashion, and offers a great selection of cotton clothing.
48. ABLE: ABLE offers ethical and stylish cotton clothing, supporting women artisans.
49. People Tree: People Tree focuses on fair trade and sustainable fashion, with some cotton options.
50. Enza Costa: Enza Costa creates luxury basics with a focus on high-quality cotton and a minimalist aesthetic.
51. Bella+Canvas: Bella+Canvas is known for its soft and comfortable cotton tees and other apparel, perfect for printing and customization.
52. Next Level Apparel: Next Level Apparel offers high-quality cotton blanks for printing and customization, known for their softness and durability.
53. Gildan: Gildan is a popular brand for affordable and durable cotton basics, often used for promotional and custom apparel.
54. Fruit of the Loom: Fruit of the Loom provides a range of affordable cotton basics, perfect for everyday wear.
55. Hanes: Hanes offers a wide variety of cotton undergarments and basics, known for their comfort and value.
56. Champion: Champion is famous for its classic cotton sportswear and athleisure wear.
57. Adidas: Adidas offers a range of cotton apparel, including t-shirts, hoodies, and tracksuits.
58. Nike: Nike provides a variety of cotton clothing for sports and everyday wear.
59. Under Armour: Under Armour offers cotton-blend apparel for workouts and casual wear.
60. Athleta: Athleta offers a range of cotton activewear and athleisure wear.
61. Lululemon: Lululemon creates high-quality cotton blend activewear and casual wear.
62. Vuori: Vuori offers comfortable and stylish cotton apparel for both workouts and everyday wear.
63. Outdoor Voices: Outdoor Voices provides a range of cotton activewear and casual wear.
64. Prana: Prana offers sustainable and eco-friendly cotton clothing for outdoor adventures.
65. Patagonia: Patagonia is all about outdoor gear, and many of their everyday wear options use cotton.
66. REI Co-op: REI Co-op offers a selection of cotton clothing for outdoor activities and everyday wear.
67. Carhartt: Carhartt is known for its durable and rugged cotton workwear.
68. Dickies: Dickies provides a range of cotton workwear and casual wear.
69. Wrangler: Wrangler offers a selection of cotton denim and casual wear.
70. Lee: Lee is known for its classic cotton denim and casual wear.
71. American Eagle Outfitters: American Eagle offers a range of trendy cotton clothing.
72. Abercrombie & Fitch: Abercrombie & Fitch provides stylish cotton apparel for casual wear.
73. Hollister: Hollister offers trendy and casual cotton clothing for a younger demographic.
74. Aeropostale: Aeropostale provides a range of casual cotton clothing.
75. Express: Express offers stylish cotton apparel for work and play.
76. Banana Republic: Banana Republic creates classic cotton clothing for both work and casual wear.
77. Ann Taylor: Ann Taylor offers sophisticated cotton clothing for women.
78. Loft: Loft provides stylish and comfortable cotton clothing for women.
79. White House Black Market: White House Black Market creates elegant cotton clothing for women.
80. J.Jill: J.Jill offers comfortable and relaxed cotton clothing.
81. Lands' End: Lands' End provides a range of classic cotton clothing for the whole family.
82. Eddie Bauer: Eddie Bauer offers casual and outdoor-inspired cotton clothing.
83. Old Navy: Old Navy provides affordable and trendy cotton clothing for the whole family.
84. Gap: Gap is a classic brand that offers a range of cotton clothing, perfect for everyday wear.
85. Uniqlo: Uniqlo offers a wide range of affordable and stylish cotton basics, from t-shirts to jeans.
86. Cotton On: Cotton On offers trendy and affordable cotton clothing and accessories.
87. Boohoo: Boohoo provides trendy and budget-friendly cotton clothing.
88. PrettyLittleThing: PrettyLittleThing offers trendy and affordable cotton clothing.
89. Fashion Nova: Fashion Nova is known for its trendy and affordable cotton clothing.
90. Shein: Shein offers a vast selection of affordable and trendy cotton clothing.
91. Romwe: Romwe provides a range of trendy and affordable cotton clothing.
92. Zaful: Zaful offers trendy and affordable cotton clothing.
93. Wish: Wish offers a wide variety of affordable cotton clothing and accessories.
94. Amazon Essentials: Amazon Essentials offers a range of affordable cotton basics.
95. Goodthreads: Goodthreads offers stylish and affordable cotton clothing on Amazon.
96. The Drop: The Drop offers trendy and affordable cotton clothing on Amazon.
97. Daily Ritual: Daily Ritual offers comfortable and affordable cotton basics on Amazon.
98. Core 10: Core 10 provides affordable and stylish cotton activewear on Amazon.
99. Free Assembly: Free Assembly offers stylish and affordable cotton clothing at Walmart.
100. Sofia Jeans by Sofia Vergara: Sofia Jeans by Sofia Vergara offers stylish and affordable denim and cotton clothing at Walmart.

This list should give you a fantastic starting point for exploring the world of 100% cotton clothing brands in the USA. Happy shopping, friends! And remember, comfort and style can go hand in hand with the incredible goodness of cotton. Have fun finding your next favorite piece!